• Users Online: 172
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2020  |  Volume : 10  |  Issue : 1  |  Page : 6-12

The IMPACT of chronic rhinosinusitis on olfaction (immunohistochemical study)


1 Department of Otorhinolaryngology, Ain Shams University, Cairo, Egypt
2 Department of Pathology, Ain Shams University, Cairo, Egypt

Correspondence Address:
Mina F Saleeb
Otorhinolarygology, Ain Shams University
Egypt
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/pajr.pajr_5_20

Rights and Permissions

Introduction Chronic sinusitis is considered one of the most important causes of olfactory dysfunction, and this is attributed to the obstructive effect of swollen mucosa and nasal polyps or inflammatory process in the olfactory mucosa. Patients and methods This study enrolled 60 patients [20 chronic rhinosinusitis with nasal polyps (CRSwp), chronic rhinosinusitis without nasal polyps (20 CRSsp), and 20 control] and used nestin antibody, a marker found in olfactory mucosa and directly related to function, to prove the etiology of olfactory dysfunction in CRS. Results It was found that nestin staining is decreased in both cases groups, but on the contrary, patients with CRSwp have more olfactory dysfunction than patients with CRSsp. This means that the inflammatory process is strongly present in both case groups; however, the presence of polyps increases olfactory function loss. Conclusion This study led to an important conclusion that both obstructive and inflammatory causes contribute to olfactory dysfunction in patients with CRS.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed215    
    Printed22    
    Emailed0    
    PDF Downloaded41    
    Comments [Add]    

Recommend this journal